BDBM561454 US11390625, Compound 34::US11390625, Example 34

SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1

InChI Key InChIKey=ZYSKXRAGBGLELB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 561454   

TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 7.92nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 0.218nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 0.160nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 0.218nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed