BDBM561251 N-(3-fluoro-4- (1H-pyrazol-4- yl)phenyl)-2- (2-(thiazol-2- yl)-1H-indol-6- yl)pyrimidin-4- amine::US11390609, Compound TDI01908::US20230285393, Compound 128

SMILES Fc1cc(Nc2ccnc(n2)-c2ccc3cc([nH]c3c2)-c2nccs2)ccc1-c1cn[nH]c1

InChI Key InChIKey=DDRNUVFEJKPILV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 561251   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561251(N-(3-fluoro-4- (1H-pyrazol-4- yl)phenyl)-2- (2-(th...)
Affinity DataIC50: 27nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561251(N-(3-fluoro-4- (1H-pyrazol-4- yl)phenyl)-2- (2-(th...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2 [1-119](Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561251(N-(3-fluoro-4- (1H-pyrazol-4- yl)phenyl)-2- (2-(th...)
Affinity DataIC50: 27nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent