BDBM561180 1-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)-2-(2- (3,3- difluorocyclobutane-1- carbonyl)isoindolin-5- yl)-5,7-dihydro-6H- pyrrolo[3,4-d]pyrimidin- 6-yl)ethan-1-one::US11390609, Compound TDI01587

SMILES CC(=O)N1Cc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2C1)-c1ccc2CN(Cc2c1)C(=O)C1CC(F)(F)C1

InChI Key InChIKey=SQCYXHRHJMIJLA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561180   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561180(1-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)-2-(2- (3,...)
Affinity DataIC50: 25nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561180(1-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)-2-(2- (3,...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent