BDBM561115 (6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimidin- 2-yl)-1H-indol-2- yl)(3,3- difluoropyrrolidin-1- yl)methanone::US11390609, Compound TDI01463

SMILES FC1(F)CCN(C1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1

InChI Key InChIKey=VDNSCMUSKRBVAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561115   

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561115((6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561115((6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimidin...)
Affinity DataIC50: 11nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent