BDBM557875 1-(3-((7-methoxy-4- (phenylamino)quinazolin-6- yl)oxy)azetidin-1-yl)prop-2- en-1-one::US11365189, Ex. No. 41
SMILES COc1cc2ncnc(Nc3ccccc3)c2cc1OC1CN(C1)C(=O)C=C
InChI Key InChIKey=KIJZQRPGXWEDEC-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 557875
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 40nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-780,'GSP',781-1255](Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 18nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'VC',777-1255](Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 24nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair