BDBM554529 (5RS)-5-{[(3S)-3-Fluoropyrrolidin-1-yl]carbonyl}-2-[4-fluoro-3-(trifluoromethyl)benzyl]-7-(4,4,4-trifluorobutanoyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one (Isomer 1)::US11337973, Example 33

SMILES F[C@H]1CCN(C1)C(=O)C1CN(Cc2nn(Cc3ccc(F)c(c3)C(F)(F)F)c(=O)n12)C(=O)CCC(F)(F)F

InChI Key InChIKey=OIDRWVNKZVXPIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 554529   

TargetProlyl endopeptidase(Human)
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US Patent
LigandPNGBDBM554529((5RS)-5-{[(3S)-3-Fluoropyrrolidin-1-yl]carbonyl}-2...)
Affinity DataIC50: 280nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
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Date in BDB:
8/28/2022
Entry Details
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