BDBM554517 (5RS)—N-Cyclopropyl-2-(4-methylbenzyl)-3-oxo-5-(pyrrolidin-1-ylcarbonyl)-2,5,6,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7(3H)-carboxamide (Racemate)::US11337973, Example 21::US11337973, Example 22::US11337973, Example 23

SMILES Cc1ccc(Cn2nc3CN(CC(C(=O)N4CCCC4)n3c2=O)C(=O)NC2CC2)cc1

InChI Key InChIKey=CILOBFUZWATMJO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 554517   

TargetProlyl endopeptidase(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM554517(US11337973, Example 23 | US11337973, Example 22 | ...)
Affinity DataIC50: 0.325nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM554517(US11337973, Example 23 | US11337973, Example 22 | ...)
Affinity DataIC50: 120nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM554517(US11337973, Example 23 | US11337973, Example 22 | ...)
Affinity DataIC50: 0.350nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent