BDBM554510 (5RS)-7-(Cyclopropylcarbonyl)-2-(4-methylbenzyl)-5-(pyrrolidin-1-ylcarbonyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one (Racemate)::US11337973, Example 14::US11337973, Example 15::US11337973, Example 16

SMILES Cc1ccc(Cn2nc3CN(CC(C(=O)N4CCCC4)n3c2=O)C(=O)C2CC2)cc1

InChI Key InChIKey=CFKAIUPMMOAVRU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 554510   

TargetProlyl endopeptidase(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM554510(US11337973, Example 15 | US11337973, Example 16 | ...)
Affinity DataIC50: 0.870nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM554510(US11337973, Example 15 | US11337973, Example 16 | ...)
Affinity DataIC50: 72.5nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM554510(US11337973, Example 15 | US11337973, Example 16 | ...)
Affinity DataIC50: 0.170nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent