BDBM554501 US11337973, Example 5::tert-Butyl (5RS)-5-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-fluoro-3-(trifluoromethyl)benzyl]-3-oxo-2,5,6,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7(3H)-carboxylate (Diastereomer Mixture; 2 Isomers)

SMILES CC(C)(C)OC(=O)N1CC(C(=O)N2CC[C@H](F)C2)n2c(C1)nn(Cc1ccc(F)c(c1)C(F)(F)F)c2=O

InChI Key InChIKey=FWPYOUADGNRMOD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 554501   

TargetProlyl endopeptidase(Human)
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US Patent
LigandPNGBDBM554501(tert-Butyl (5RS)-5-{[(3S)-3-fluoropyrrolidin-1-yl]...)
Affinity DataIC50: 0.510nMAssay Description:To recombinant full-length human prolyl endopeptidase (PREP, R&D-Systems, 4308-SE; final concentration, for example, 0.4 nM, volume: 25 al) in reacti...More data for this Ligand-Target Pair
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Date in BDB:
8/28/2022
Entry Details
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