BDBM554420 US11332451, Compound I-78::US11370764, Compound I-78::US11377428, Compound I-78

SMILES CN1c2cc(ccc2OC[C@H](NC(=O)c2n[nH]c(Cc3cccc(F)c3)n2)C1=O)C#CC(C)(C)O

InChI Key InChIKey=KHMHEHKYQQECLX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 554420   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM554420(US11377428, Compound I-78 | US11332451, Compound I...)
Affinity DataIC50: 33.4nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM554420(US11377428, Compound I-78 | US11332451, Compound I...)
Affinity DataIC50: 33.4nMAssay Description:ADP-Glo (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM554420(US11377428, Compound I-78 | US11332451, Compound I...)
Affinity DataIC50: 33.4nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
Go to US Patent