BDBM553003 N-(4-(3-(dimethylamino) pyrrolidin-1-yl)-6-fluoro-3'- (morpholinomethyl)-[1,1'- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3- carboxamide::US11319299, Example 53

SMILES CN(C)C1CCN(C1)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1

InChI Key InChIKey=ZUVJNJIAGSBLES-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 553003   

TargetMLL1-WRAD2 complex(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM553003(N-(4-(3-(dimethylamino) pyrrolidin-1-yl)-6-fluoro-...)
Affinity DataIC50: 1.49E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetWD repeat-containing protein 5(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM553003(N-(4-(3-(dimethylamino) pyrrolidin-1-yl)-6-fluoro-...)
Affinity DataKd:  5.70nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In DepthDetails
US Patent