BDBM552971 4-fluoro-N-[4-fluoro-5- (2-morpholin-4- ylpyrimidin-5-yl)-2- [(3R,5S)-3,4,5- trimethylpiperazin-1- yl]phenyl]-3- methylbenzamide::US11319299, Example 25

SMILES C[C@H]1CN(C[C@@H](C)N1C)c1cc(F)c(cc1NC(=O)c1ccc(F)c(C)c1)-c1cnc(nc1)N1CCOCC1

InChI Key InChIKey=CRLXCSCPDXUEGK-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552971   

TargetMLL1-WRAD2 complex(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM552971(4-fluoro-N-[4-fluoro-5- (2-morpholin-4- ylpyrimidi...)
Affinity DataIC50: 3.34E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetWD repeat-containing protein 5(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM552971(4-fluoro-N-[4-fluoro-5- (2-morpholin-4- ylpyrimidi...)
Affinity DataKd:  8.5nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In DepthDetails
US Patent