BDBM551631 2-(4-((3R,5S or 3S,5R)-3-(5-amino-7,9-difluoro- [1,2,4]triazolo[1,5-c]quinazolin-2-yl)-5-methylpiperidin- 1-yl)-3-methyl-1H-pyrazol-1-yl)-2-methylpropan-1-ol::US11312719, Example 177::US11312719, Example 178

SMILES CC1CC(CN(C1)c1cn(nc1C)C(C)(C)CO)c1nc2c3cc(F)cc(F)c3nc(N)n2n1

InChI Key InChIKey=FBXXMLFCQCJNKT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 551631   

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551631(2-(4-((3R,5S or 3S,5R)-3-(5-amino-7,9-difluoro- [1...)
Affinity DataIC50: 154nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551631(2-(4-((3R,5S or 3S,5R)-3-(5-amino-7,9-difluoro- [1...)
Affinity DataIC50: 3.96E+3nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551631(2-(4-((3R,5S or 3S,5R)-3-(5-amino-7,9-difluoro- [1...)
Affinity DataIC50: 0.600nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551631(2-(4-((3R,5S or 3S,5R)-3-(5-amino-7,9-difluoro- [1...)
Affinity DataIC50: 11.5nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent