BDBM550536 6′-[(6-{[(3S)-3-(Dimethylamino)pyrrolidin-1-yl]carbonyl}thieno[2,3-d]pyrimidin-4-yl)amino]-8′-methyl-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione::US11311520, Example 30

SMILES CN(C)[C@H]1CCN(C1)C(=O)c1cc2c(Nc3cc(C)c4C(=O)NC5(CCCCC5)n4c3=O)ncnc2s1

InChI Key InChIKey=MLIDBVPZIJOWMP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550536   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM550536(6′-[(6-{[(3S)-3-(Dimethylamino)pyrrolidin-1-...)
Affinity DataIC50: 3.20nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent