BDBM548727 WO2022098806, Compound 1-123

SMILES Cc1c2NCCOc2ncc1-c1ccc2cnc(Nc3ccc(CS(C)(=O)=O)cc3)nc2c1

InChI Key InChIKey=RCCPGGOXAZPPJZ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 548727   

LigandPNGBDBM548727(WO2022098806, Compound 1-123)
Affinity DataIC50: 0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022098806

LigandPNGBDBM548727(WO2022098806, Compound 1-123)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM548727(WO2022098806, Compound 1-123)
Affinity DataIC50: 2nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation at Ser376 residue preincubated for 60 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM548727(WO2022098806, Compound 1-123)
Affinity DataEC50:  11nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed