BDBM544498 (rac)-13-fluoro-10,12-dimethyl-1-(3-((5,6,7,8-tetrahydronaphthalen-1-yl)oxy)propyl)-4,5,6,7,9,10-hexahydropyrazolo[4′,3′:9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid::US11286263, Example 34

SMILES Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5CCCCc45)c4ccc(F)c(-c12)c34

InChI Key InChIKey=YLZNJPDNDBOUOL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 544498   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
The Broad Institute

US Patent
LigandPNGBDBM544498(US11286263, Example 34 | (rac)-13-fluoro-10,12-dim...)
Affinity DataIC50: 1.30nMAssay Description:MCL-1 Assay: In the assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
Go to US Patent

TargetBcl-2-like protein 1 [1-212](Human)
The Broad Institute

US Patent
LigandPNGBDBM544498(US11286263, Example 34 | (rac)-13-fluoro-10,12-dim...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-XL Assay: In the assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2 [1-211](Human)
The Broad Institute

US Patent
LigandPNGBDBM544498(US11286263, Example 34 | (rac)-13-fluoro-10,12-dim...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2 Assay: In the assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
Go to US Patent