BDBM544484 (rac)-1-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-13-fluoro-11,12-dimethyl-4,5,6,7,9,11-hexahydropyrazolo[4′,3′:9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid::US11286263, Example 20

SMILES Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cc(C)c(Cl)c(C)c4)c4ccc(F)c-2c34)nn1C

InChI Key InChIKey=NGKIMZZDVOLHFE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 544484   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
The Broad Institute

US Patent
LigandPNGBDBM544484(US11286263, Example 20 | (rac)-1-(3-(4-chloro-3,5-...)
Affinity DataIC50: 1.5nMAssay Description:MCL-1 Assay: In the assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1....More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBcl-2-like protein 1 [1-212](Human)
The Broad Institute

US Patent
LigandPNGBDBM544484(US11286263, Example 20 | (rac)-1-(3-(4-chloro-3,5-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-XL Assay: In the assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetApoptosis regulator Bcl-2 [1-211](Human)
The Broad Institute

US Patent
LigandPNGBDBM544484(US11286263, Example 20 | (rac)-1-(3-(4-chloro-3,5-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2 Assay: In the assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1....More data for this Ligand-Target Pair
In DepthDetails
US Patent