BDBM544283 (M)-N-[2-[6- Chloro-4- [(2S,5R)-2,5- dimethyl-4- prop-2-enoyl- piperazin-1-yl]- 1-(2-isopropyl- 4-methyl-3- pyridyl)-2-oxo- pyrido[2,3- d]pyrimidin-7- yl]-3-fluoro- phenyl]cyclopro panecarboxamide::US11285156, Ex.# 129-9

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1c(F)cccc1NC(=O)C1CC1

InChI Key InChIKey=OESGXUZUJPUGAY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544283   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544283(US11285156, Ex.# 129-9 | (M)-N-[2-[6- Chloro-4- [(...)
Affinity DataIC50: 8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent