BDBM544213 6-Chloro-1-(4- cyclopropyl-6- isopropyl-pyrimidin-5- yl)-4-[(2S,5R)-2,5- dimethyl-4-prop-2- enoyl-piperazin-1-yl]- 7-(2- fluorophenyl)pyrido[2, 3-d]pyrimidin-2-one::US11285156, Ex.# 108-1-1::US11285156, Ex.# 108-1-2

SMILES CC(C)c1ncnc(C2CC2)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1F

InChI Key InChIKey=DFFWYBDBBIKPEO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 544213   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544213(US11285156, Ex.# 108-1-2 | 6-Chloro-1-(4- cyclopro...)
Affinity DataIC50: 6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544213(US11285156, Ex.# 108-1-2 | 6-Chloro-1-(4- cyclopro...)
Affinity DataIC50: 8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent