BDBM538662 NCGC 00249362::US11254667, Compound I-63::US11542261, Compound I-63

SMILES Clc1ccn2c(cnc2c1)-c1cccc(NC2CNC2)n1

InChI Key InChIKey=CBQCUBRMCPKDKA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 538662   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538662(NCGC 00249362 | US11254667, Compound I-63 | US1154...)
Affinity DataIC50: 973nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538662(NCGC 00249362 | US11254667, Compound I-63 | US1154...)
Affinity DataIC50: 973nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538662(NCGC 00249362 | US11254667, Compound I-63 | US1154...)
Affinity DataIC50: 973nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent