BDBM538059 4-(3-(1-(2-chloropyrimidin- 4-yl)-4-oxido-1,4- azaphosphinan-4-yl)-4- fluorobenzyl)phthalazin- 1(2H)-one::US11248013, Example 17

SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1P1(=O)CCN(CC1)c1ccnc(Cl)n1

InChI Key InChIKey=OWIYWCUWDVRVDE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 538059   

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538059(4-(3-(1-(2-chloropyrimidin- 4-yl)-4-oxido-1,4- aza...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent