BDBM536489 (S)-5-(1-(2-((3- chloro-6-(2,4- dimethylpiperazin- 1-yl)-2-fluoro- pyridin-4-yl)amino)- 2-oxoethyl)-4-oxo- 4,6,7,8-tetrahydro-1H- dipyrrolo[1,2-a:2',3'- d]pyrimidin-3-yl)-2- hydroxy-3,4-dimethoxy- benzamide::US11242351, Compound I-68

SMILES COc1c(O)c(cc(-c2cn(CC(=O)Nc3cc(nc(F)c3Cl)N3CCN(C)C[C@@H]3C)c3nc4CCCn4c(=O)c23)c1OC)C(N)=O

InChI Key InChIKey=SEAWHCOUDFAAMJ-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 536489   

TargetB-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429](Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM536489((S)-5-(1-(2-((3- chloro-6-(2,4- dimethylpiperazin-...)
Affinity DataKd:  31.3nMAssay Description:This assay was used to determine whether compounds inhibit the interaction between the BTB domain of BCL6 and a peptide derived from the BCL6 binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent