BDBM536239 (2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthalene-1,5'-[1,2,4]oxadiazol]-3'-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 131.3::US11242344, Example 131.4

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)CC1C1=NOC2(CCCc3ccccc23)N1)c1cc(C)no1

InChI Key InChIKey=DYVCCEQFPYNQOG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 536239   

LigandPNGBDBM536239(US11242344, Example 131.4 | (2R)-1-((4R)-2-(3,4-di...)
Affinity DataIC50: 1.96E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
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Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536239(US11242344, Example 131.4 | (2R)-1-((4R)-2-(3,4-di...)
Affinity DataIC50: 2.30E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM536239(US11242344, Example 131.4 | (2R)-1-((4R)-2-(3,4-di...)
Affinity DataIC50: 1.99E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536239(US11242344, Example 131.4 | (2R)-1-((4R)-2-(3,4-di...)
Affinity DataIC50: 2.00E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent