BDBM536209 (R)-1-((2S,4R)-4-hydroxy-2-(1-oxa-2,4-diazaspiro[4.4]non-2-en-3-yl)pyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 127.2

SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC2(CCCC2)N1)c1cc(C)no1

InChI Key InChIKey=AGJJNPYHMLNPDT-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536209   

LigandPNGBDBM536209((R)-1-((2S,4R)-4-hydroxy-2-(1-oxa-2,4-diazaspiro[4...)
Affinity DataIC50: 5.08E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Date in BDB:
6/10/2022
Entry Details
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LigandPNGBDBM536209((R)-1-((2S,4R)-4-hydroxy-2-(1-oxa-2,4-diazaspiro[4...)
Affinity DataKd:  1.64E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
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Date in BDB:
6/10/2022
Entry Details
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Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536209((R)-1-((2S,4R)-4-hydroxy-2-(1-oxa-2,4-diazaspiro[4...)
Affinity DataIC50: 7.32E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent