BDBM536192 2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-5-yl)butanoyl) pyrrolidin-2-yl)-5-methyl-5-(4-(4-methylthiazol-5-yl)phenyl)-1, 5-dihydro-4H-imidazol-4-one::US11242344, Example 104.1

SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(C)no1

InChI Key InChIKey=FSKZKSWIQLYFSC-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536192   

LigandPNGBDBM536192(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-...)
Affinity DataIC50: 2.03E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Date in BDB:
6/10/2022
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LigandPNGBDBM536192(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-...)
Affinity DataKd:  3.59E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent