BDBM536183 2-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-methylthiazol-5-yl)phenyl)-4-oxo-4,5-dihydro-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)isoindolin-1-one::US11242344, Example 123.1::US11242344, Example 123.2

SMILES CC(C)[C@H](N1Cc2ccccc2C1=O)C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C

InChI Key InChIKey=ZERUXLRPTNAVAJ-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536183   

LigandPNGBDBM536183(US11242344, Example 123.2 | 2-((2S)-1-((4R)-4-hydr...)
Affinity DataIC50: 4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Date in BDB:
6/10/2022
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LigandPNGBDBM536183(US11242344, Example 123.2 | 2-((2S)-1-((4R)-4-hydr...)
Affinity DataKd:  5.56E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
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Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536183(US11242344, Example 123.2 | 2-((2S)-1-((4R)-4-hydr...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
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LigandPNGBDBM536183(US11242344, Example 123.2 | 2-((2S)-1-((4R)-4-hydr...)
Affinity DataIC50: 4.68E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
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LigandPNGBDBM536183(US11242344, Example 123.2 | 2-((2S)-1-((4R)-4-hydr...)
Affinity DataKd:  3.98E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536183(US11242344, Example 123.2 | 2-((2S)-1-((4R)-4-hydr...)
Affinity DataIC50: 5.48E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent