BDBM536180 N-((2S)-1-((4R)-2-(5-(4-Bromophenyl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-4-hydroxypyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)acetamide (2 Single Stereoisomers)::US11242344, Example 102.2::US11242344, Example 102.3

SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)CC1C1=NC(=O)C(C)(N1)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1)C(C)(C)C

InChI Key InChIKey=VPLHYGGQVCNXMG-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 536180   

LigandPNGBDBM536180(N-((2S)-1-((4R)-2-(5-(4-Bromophenyl)-5-methyl-4-ox...)
Affinity DataIC50: 9.31E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Date in BDB:
6/10/2022
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LigandPNGBDBM536180(N-((2S)-1-((4R)-2-(5-(4-Bromophenyl)-5-methyl-4-ox...)
Affinity DataKd:  4.38E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
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LigandPNGBDBM536180(N-((2S)-1-((4R)-2-(5-(4-Bromophenyl)-5-methyl-4-ox...)
Affinity DataIC50: 4.33E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM536180(N-((2S)-1-((4R)-2-(5-(4-Bromophenyl)-5-methyl-4-ox...)
Affinity DataKd:  1.07E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent