BDBM533757 Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-N-hydroxynicotinamide ::US11225492, Compound 17

SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)C(=O)NO)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=OSUJSRFDMDLCHS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 533757   

TargetCyclin-A2 [177-432]/Cyclin-dependent kinase 2(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533757(US11225492, Compound 17 | Preparation of 6-((6-ace...)
Affinity DataIC50: 50nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533757(US11225492, Compound 17 | Preparation of 6-((6-ace...)
Affinity DataIC50: 500nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533757(US11225492, Compound 17 | Preparation of 6-((6-ace...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533757(US11225492, Compound 17 | Preparation of 6-((6-ace...)
Affinity DataIC50: 500nMAssay Description:The inhibitory effect of compounds on HDAC-1, HDAC-2 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533757(US11225492, Compound 17 | Preparation of 6-((6-ace...)
Affinity DataIC50: 50nMAssay Description:The inhibitory effect of compounds on HDAC-1, HDAC-2 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent