BDBM533726 2-(5-(2,7-Diazaspiro[3.5]nonan-7-yl)pyridin-2-ylamino)-6-acetyl-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one ::US11225492, Compound 3

SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCC4(CNC4)CC3)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=OGCNSEGYUZELLA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 533726   

TargetCyclin-A2 [177-432]/Cyclin-dependent kinase 2(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533726(US11225492, Compound 3 | 2-(5-(2,7-Diazaspiro[3.5]...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533726(US11225492, Compound 3 | 2-(5-(2,7-Diazaspiro[3.5]...)
Affinity DataIC50: 25nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM533726(US11225492, Compound 3 | 2-(5-(2,7-Diazaspiro[3.5]...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
Go to US Patent