BDBM532158 US11208418, Example 3

SMILES OC(=O)c1ccc2CC3(CC3)c3nc(OCc4c(onc4-c4ccccc4OC(F)(F)F)C4CC4)ccc3Oc2c1

InChI Key InChIKey=LSXGXKRGTMLNJP-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 532158   

TargetBile acid receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM532158(US11208418, Example 3)
Affinity DataEC50:  8.60nMAssay Description:Purchasing Invitrogen PV4833 Kit.Step 1, the compound was weighed and dissolved in 100% DMSO, the highest concentration is 3000 μM, and then dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetBile acid receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM532158(US11208418, Example 3)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 15 mins by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed