BDBM531296 US11208399, Example 53

SMILES CN1CCC[C@H](C1)Nc1cc(c(nn1)-c1ccc(cc1O)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=BGHBRFNKKNQTOB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 531296   

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandPNGBDBM531296(US11208399, Example 53)
Affinity DataIC50: 0.400nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Novartis

US Patent
LigandPNGBDBM531296(US11208399, Example 53)
Affinity DataIC50: 3.30E+4nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM531296(US11208399, Example 53)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed