BDBM525544 US11174245, # I-222

SMILES CN1CCN(Cc2ccc3[nH]\c(=N/C(=O)c4cc(C)nc(c4)-c4cnn(C)c4)n([C@@H]4CC[C@H](O)CC4)c3c2)CC1

InChI Key InChIKey=VZPXZUQUHMOTEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525544   

TargetEpidermal growth factor receptor [695-745,751-1022,T790M,C797S](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525544(US11174245, # I-222)
Affinity DataIC50: 0.200nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525544(US11174245, # I-222)
Affinity DataIC50: 0.600nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [695-1022](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525544(US11174245, # I-222)
Affinity DataIC50: 318nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent