BDBM525460 US11174245, # I-055

SMILES COC(=O)Cc1ccc2n(CC(C)(C)O)\c(=N\C(=O)c3ccnc(c3)-c3cnn(C)c3)[nH]c2c1

InChI Key InChIKey=XBAAZPRQPZXINZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525460   

TargetEpidermal growth factor receptor [695-745,751-1022,T790M,C797S](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525460(US11174245, # I-055)
Affinity DataIC50: 7.30nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525460(US11174245, # I-055)
Affinity DataIC50: 86.9nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [695-1022](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM525460(US11174245, # I-055)
Affinity DataIC50: 2.63E+4nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent