BDBM521422 6-(4-ethoxy- 2,3-difluoro- phenyl)-5-[2- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxypyrimidin- 5-yl]-8,9- dihydro-7H- benzo[7]annulen- 2-ol::US11149031, Example 246

SMILES CCOc1ccc(c(F)c1F)C1=C(c2cnc(O[C@H]3CCN(CCCF)C3)nc2)c2ccc(O)cc2CCC1

InChI Key InChIKey=MZANDHNDIRFPST-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521422   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521422(6-(4-ethoxy- 2,3-difluoro- phenyl)-5-[2- [(3S)-1-(...)
Affinity DataIC50: 2nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521422(6-(4-ethoxy- 2,3-difluoro- phenyl)-5-[2- [(3S)-1-(...)
Affinity DataIC50: 42nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521422(6-(4-ethoxy- 2,3-difluoro- phenyl)-5-[2- [(3S)-1-(...)
Affinity DataIC50: 26nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In DepthDetails
US Patent