BDBM518799 US11117865, Compound ZL0591

SMILES OC1CCN(C[C@@H]2CCCN2S(=O)(=O)c2ccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)cc2)CC1

InChI Key InChIKey=CFXFHVGCTLQYSO-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 518799   

TargetBromodomain testis-specific protein [22-138](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.19E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.99E+3nMAssay Description:Binding affinity BRDT BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.22E+3nMAssay Description:Binding affinity BRDT BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.02E+3nMAssay Description:Binding affinity BRD3 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.10E+3nMAssay Description:Binding affinity BRD3 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.38E+3nMAssay Description:Binding affinity BRD2 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 742nMAssay Description:Binding affinity BRD2 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.17E+3nMAssay Description:Binding affinity human BRD4 BD2 incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 93nMAssay Description:Binding affinity recombinant human BRD4 BD1 (42 to 168 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [342-460](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.17E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 96nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [287-359](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.95E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 729nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.94E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.08E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.35E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 729nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.17E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 96nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [287-359](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.95E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [22-138](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.19E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.94E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 2.08E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
University Of Texas

US Patent
LigandPNGBDBM518799(US11117865, Compound ZL0591)
Affinity DataIC50: 1.35E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent