BDBM518531 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one hydrochloride::US11124518, Example 6::US11299493, Compound 1.1

SMILES CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc4CCNCc4c3)nc12

InChI Key InChIKey=JZNQZUXXRGOTBT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 518531   

TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518531(US11124518, Example 6 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 10nMAssay Description:Wee 1 kinase was determined by using Flurorescence Resonance Energy Transfer (FRET) assay. In 384-well plates, Wee1 kinase (2 nM final concentration)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518531(US11124518, Example 6 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518531(US11124518, Example 6 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 2.40nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
Go to US Patent