BDBM518530 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one::US11124518, Example 5::US11299493, Compound 1.9

SMILES CN1CCc2ccc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(CC=C)c4=O)cc2C1

InChI Key InChIKey=YAJRPJIUYSGGEL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 518530   

TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518530(US11124518, Example 5 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 10nMAssay Description:Wee 1 kinase was determined by using Flurorescence Resonance Energy Transfer (FRET) assay. In 384-well plates, Wee1 kinase (2 nM final concentration)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518530(US11124518, Example 5 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518530(US11124518, Example 5 | 2-Allyl-1-(6-(2-hydroxypro...)
Affinity DataIC50: 1nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
Go to US Patent