BDBM518431 US11124500, Example 24a

SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(C[C@@H](O)CO)c1

InChI Key InChIKey=XVQYJNLYUFGIDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518431   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM518431(US11124500, Example 24a)
Affinity DataIC50: 6.06nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518431(US11124500, Example 24a)
Affinity DataIC50: 9.99nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent