BDBM517533 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-(3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl)picolinamide::USRE48711, Example 140

SMILES O=C(Nc1cccc(c1)-c1nncn1C1CC1)c1cc(ccn1)-n1cnc(c1)C1CC1

InChI Key InChIKey=ZGCMQKWOUIMBEP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 517533   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandPNGBDBM517533(USRE48711, Example 140 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 9nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandPNGBDBM517533(USRE48711, Example 140 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ASK1 (unknown origin) by competitive TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandPNGBDBM517533(USRE48711, Example 140 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandPNGBDBM517533(USRE48711, Example 140 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandPNGBDBM517533(USRE48711, Example 140 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant ASK1 using MBP as substrate preincubated for 1 hr followed by reagent addition incubated for 40 mins by ATP-Glo kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed