BDBM517035 (R)-6-cyclopropyl-N-(3- fluoro-4-((3-((1- hydroxypropan-2- yl)amino)-1H- pyrazolo[3,4-b]pyridin- 4-yl)oxy)phenyl)-2-(4- fluorophenyl)-3-oxo- 2,3-dihydropyridazine- 4-carboxamide::US11104676, Example 105

SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(nn(-c5ccc(F)cc5)c4=O)C4CC4)cc3F)c12

InChI Key InChIKey=OXQCVUDNHCLLCA-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 517035   

TargetHepatocyte growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 1.70nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [1-13,15-1390](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 2.80nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [D1228H](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 3.90nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [D1228N](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 4.90nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [F1200I](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 2.5nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [L1195V](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 28.3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [Y1230C](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 3.10nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [Y1230H](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 4.10nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor [Y1230S](Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 2.30nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 1.10E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 4.00E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Array Biopharma

US Patent
LigandPNGBDBM517035(US11104676, Example 105 | (R)-6-cyclopropyl-N-(3- ...)
Affinity DataIC50: 9.80E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen Eu Kinase Binding technolo...More data for this Ligand-Target Pair
In DepthDetails
US Patent