BDBM513228 2-(4,4-difluorocyclohexyl)-6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one::US11091471, Example 96::US20240279218, Example 96

SMILES Cc1onc(c1COc1cc2CN(C3CCC(F)(F)CC3)C(=O)c2cn1)-c1ccc(C)nc1

InChI Key InChIKey=WPSKGYBCTJQZGB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 513228   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513228(2-(4,4-difluorocyclohexyl)-6-((5-methyl-3-(6-methy...)
Affinity DataKi:  7.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
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TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513228(2-(4,4-difluorocyclohexyl)-6-((5-methyl-3-(6-methy...)
Affinity DataKi:  7.20nMAssay Description:The affinity of compounds at GABAA receptor subtypes was measured by competition for [3H]flumazenil (85 Ci/mmol; Roche) binding to HEK293 cells expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent