BDBM513187 5-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)pyridazine-3-carboxamide::US11091471, Example 70::US20240279218, Example 70

SMILES Cc1onc(c1COc1nnc(cc1C)C(N)=O)-c1ccc(C)nc1

InChI Key InChIKey=PYEJACCXPZGJAH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 513187   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513187(5-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isox...)
Affinity DataKi:  1.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513187(5-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isox...)
Affinity DataKi:  1.20nMAssay Description:The affinity of compounds at GABAA receptor subtypes was measured by competition for [3H]flumazenil (85 Ci/mmol; Roche) binding to HEK293 cells expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent