BDBM512342 Preparation of 2-chloro-N-(4-fluoro-3-((2-((1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-4-yl)oxy)phenyl)acetamide::US11084823, Example 42

SMILES Fc1ccc(NC(=O)CCl)cc1Oc1nc(Nc2cnn(c2)C2CCOCC2)nn2cccc12

InChI Key InChIKey=KYRQUVYGCZFTQL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 512342   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM512342(Preparation of 2-chloro-N-(4-fluoro-3-((2-((1-(tet...)
Affinity DataIC50: 0.5nMAssay Description:Specifically, the inhibitory activities of JAK3 and BTK kinase were measured using a JAK3 kinase assay kit (Promega, V9441) and a BTK kinase assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM512342(Preparation of 2-chloro-N-(4-fluoro-3-((2-((1-(tet...)
Affinity DataIC50: 1.30nMAssay Description:Specifically, the inhibitory activities of JAK3 and BTK kinase were measured using a JAK3 kinase assay kit (Promega, V9441) and a BTK kinase assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
Go to US Patent