BDBM512330 Preparation of N-(4-fluoro-3-((2-((thiophen-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-4-yl)oxy)phenyl)acrylamide::US11084823, Example 30

SMILES Fc1ccc(NC(=O)C=C)cc1Oc1nc(Nc2ccsc2)nn2cccc12

InChI Key InChIKey=BDFIEYBRWPHSOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 512330   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM512330(Preparation of N-(4-fluoro-3-((2-((thiophen-3-yl)a...)
Affinity DataIC50: 7.60nMAssay Description:Specifically, the inhibitory activities of JAK3 and BTK kinase were measured using a JAK3 kinase assay kit (Promega, V9441) and a BTK kinase assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM512330(Preparation of N-(4-fluoro-3-((2-((thiophen-3-yl)a...)
Affinity DataIC50: 66.6nMAssay Description:Specifically, the inhibitory activities of JAK3 and BTK kinase were measured using a JAK3 kinase assay kit (Promega, V9441) and a BTK kinase assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
Go to US Patent