BDBM512325 Preparation of N-(4-fluoro-3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-4-yl)oxy)phenyl)acrylamide::US11084823, Example 25

SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cc(NC(=O)C=C)ccc3F)c3cccn3n2)cc1

InChI Key InChIKey=JJEZMNVRXSQYDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 512325   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM512325(Preparation of N-(4-fluoro-3-((2-((4-(4-methylpipe...)
Affinity DataIC50: 1.40nMAssay Description:Specifically, the inhibitory activities of JAK3 and BTK kinase were measured using a JAK3 kinase assay kit (Promega, V9441) and a BTK kinase assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM512325(Preparation of N-(4-fluoro-3-((2-((4-(4-methylpipe...)
Affinity DataIC50: 7.90nMAssay Description:Specifically, the inhibitory activities of JAK3 and BTK kinase were measured using a JAK3 kinase assay kit (Promega, V9441) and a BTK kinase assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
Go to US Patent