BDBM511382 1-(7-fluoro-3-(tetrahydro- 2H-pyran-4- yl)isoquinolin-8-yl)-N- methyl-3-(tetrahydro-2H- pyran-4-yl)-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide::US11058688, Example 83

SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1c(F)ccc2cc(ncc12)C1CCOCC1

InChI Key InChIKey=NFYZPGNEBRELTJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511382   

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511382(1-(7-fluoro-3-(tetrahydro- 2H-pyran-4- yl)isoquino...)
Affinity DataIC50: 16nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
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TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM511382(1-(7-fluoro-3-(tetrahydro- 2H-pyran-4- yl)isoquino...)
Affinity DataIC50: 1.94E+4nMAssay Description:The binding of 2.5 nM of BRD4(49-170) to 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) was assessed following the same procedure described for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent