BDBM511363 1-(3-cyano-2-(1-methyl- 1H-pyrazol-4-yl)quinolin- 5-yl)-N-methyl-3- (tetrahydro-2H-pyran-4- yl)-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide::US11058688, Example 64

SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C#N

InChI Key InChIKey=NRVPKHKXOCCHKA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511363   

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511363(1-(3-cyano-2-(1-methyl- 1H-pyrazol-4-yl)quinolin- ...)
Affinity DataIC50: 4nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
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TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM511363(1-(3-cyano-2-(1-methyl- 1H-pyrazol-4-yl)quinolin- ...)
Affinity DataIC50: 2.28E+4nMAssay Description:The binding of 2.5 nM of BRD4(49-170) to 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) was assessed following the same procedure described for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent