BDBM510060 N-{(1 S)-1-Cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-N2-[(3,3-difluorocyclobutyl)acetyl]-4- methyl-L-leucinamide (12)::US11351149, Example 12::WO2021250648, Example 12

SMILES CC(C)(C)C[C@H](NC(=O)CC1CC(F)(F)C1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C#N

InChI Key InChIKey=FNMVXLLBGRHAGL-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 510060   

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510060(WO2021250648, Example 12 | N-{(1 S)-1-Cyano-2-[(3S...)
Affinity DataIC50: 539nMAssay Description:The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510060(WO2021250648, Example 12 | N-{(1 S)-1-Cyano-2-[(3S...)
Affinity DataEC50:  6.33E+3nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetReplicase polyprotein 1a(2019-nCoV)
Pfizer

US Patent
LigandPNGBDBM510060(WO2021250648, Example 12 | N-{(1 S)-1-Cyano-2-[(3S...)
Affinity DataKi:  539nMAssay Description:The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent