BDBM5089 1,2,4-Oxadiazole Analogue 14d::4-[(2S)-2-[1-(4-methoxyphenyl)acetamido]-2-{[(1S)-1-(3-{[4-(trifluoromethyl)phenyl]methyl}-1,2,4-oxadiazol-5-yl)ethyl]carbamoyl}ethyl]phenoxyphosphonic acid

SMILES COc1ccc(CC(=O)N[C@@H](Cc2ccc(OP(O)(O)=O)cc2)C(=O)N[C@@H](C)c2nc(Cc3ccc(cc3)C(F)(F)F)no2)cc1

InChI Key InChIKey=LRGAHDOEHQSMEP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5089   

TargetTyrosine-protein kinase ZAP-70(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5089(4-[(2S)-2-[1-(4-methoxyphenyl)acetamido]-2-{[(1S)-...)
Affinity DataIC50: 6.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5089(4-[(2S)-2-[1-(4-methoxyphenyl)acetamido]-2-{[(1S)-...)
Affinity DataIC50: 8.70E+4nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed