BDBM5080 1,2,4-Oxadiazole Analogue 10::4-[(2S)-2-acetamido-2-{[(1S)-2-(1H-indol-3-yl)-1-(3-{[4-(trifluoromethyl)phenyl]methyl}-1,2,4-oxadiazol-5-yl)ethyl]carbamoyl}ethyl]phenoxyphosphonic acid

SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)c1nc(Cc2ccc(cc2)C(F)(F)F)no1

InChI Key InChIKey=GMOMHQHJJNLFRM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5080   

TargetTyrosine-protein kinase ZAP-70(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5080(4-[(2S)-2-acetamido-2-{[(1S)-2-(1H-indol-3-yl)-1-(...)
Affinity DataIC50: 3.20E+4nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5080(4-[(2S)-2-acetamido-2-{[(1S)-2-(1H-indol-3-yl)-1-(...)
Affinity DataIC50: 9.20E+4nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5080(4-[(2S)-2-acetamido-2-{[(1S)-2-(1H-indol-3-yl)-1-(...)
Affinity DataIC50: 5.00E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed